Ursodeoxycholic acid, S adenosyl-L-methionine ande their combination in the treatment of intrahepatic cholestasis of pregnancy(ICP)
Abstract
Aim of the Study: To compare the efficacy of the monotherapy with ursodeoxycholic acid and S- adenosyl- L-methione with combined effect of both drugs in the treatment in pregnant women with intrahepatic cholestasis of pregnancy. Methodology: All women with singleton pregnancy at 0.01).
The combined therapy led to quicker decrease of serum concentrations of bile acids and transaminases compared with UDCA monotherapy, however the results are only of borderline statistical significance. Gestational age at the time of labor and rate of prematurity were similar in all groups.
No adverse effects were noted on the fetuses or neonates with either therapy. Conclusions: Ursodeoxycholic acid is effective in improving the biochemical parametres during the treatment of ICP.
There is probably the synergistic effect with S adenosyl-L-methione. Whether the successful treatment influence the conditions of the fetus is not clear.
The good perinatal outocome is probably more due to the precise monitoring of the intrauterine well-being of the fetus. The project is supported by IGA MZ CR (No.
NH/7376-3).