Outcomes of transplantation of unrelated cord blood in children with malignant and non-malignant diseases: an Utrecht-Prague collaborative study
2009
Abstract
In conclusion, this dual centre experience shows that theoutcomes even with HLA-incompatible UCBT, withrelatively high cell doses, for malignant and non-malignantconditions is encouraging. EFS might in the future bepositively influenced when more HLA-matched grafts (sixof six on intermediate resolution) are available.
Matched ormismatched cord blood appears to be a good alternativestem cell source for SCT in malignant as well as in non-malignant diseases. More studies using uniform transplantprotocols and comparison studies (with other alternativecell sources) are warranted to better define the place ofUCB in the donor hierarchy.