Publication at Second Faculty of Medicine |
2009
Abstract
Regulation of immune responses, including anti-cancer immunosurveillance, plays an important role in the maintenance of homeostasis. Many of these key mechanisms have been described in last twenty years.
Regulatory T cells (Treg, CD4+CD25+Foxp3+) have been shown to be one of the most important components in the regulation of immune responses. Treg numbers have been shown to increase in the peripheral circulation of patients with different types of tumors.
This has been documented in correlation with the progression of head and neck squamous cell carcinoma (HNSCC).