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Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: Proteins newly identified in human breast milk

Publikace na 2. lékařská fakulta |
2006

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

Background: Breastfeeding may protect children from developing metabolic syndrome and other diseases later in life. We investigated novel proteins in human breast milk that might play a role in this process.

Methods: We used ELISA to measure adiponectin, adipocyte and epidermal fatty acid binding proteins (AFABP, EFABP), and leptin concentrations in human breast milk obtained from 59 mothers 48 h after initiation of lactation. Using a questionnaire and medical records, we collected information about the mothers and newborns.

Results: Mean (SE) adiponectin concentrations in breast milk were 13.7 (0.8), range 3.9-30.4 mu g/L; AFABP concentrations 26.7 (4.4), range 1.2-137.0 mu g/L; EFABP concentrations 18.1 (1.4), range 0.8-47.0 mu g/L; and leptin concentrations 0.50 (0.05), range 0-1.37 mu g/L. We found a significant correlation between AFABP and EFABP concentrations (r = 0.593, P < 0.0001).

Maternal EFABP concentrations were significantly higher in mothers who delivered boys than in those who delivered girls [21.7 (2.3) vs 15.4 (1.7) mu g/L, P = 0.028] and correlated with newborn birth weight (r = 0.266, P = 0.045). Maternal leptin correlated with body weight before pregnancy (r = 0.272, P = 0.043) and at delivery (r = 0.370, P = 0.005), body mass index before pregnancy (r = 0.397, P = 0.003) and at delivery (r = 0.498, P < 0.0001), body weight gain during pregnancy (r = 0.267, P = 0.047), and newborn gestational age (r = 0.266, P = 0.048).

Leptin was significantly lower in mothers who delivered preterm vs. term babies [0.30 (0.09) vs 0.60 (0.05) ug/L, P = 0.026]. Conclusions: Concentrations of adiponectin, AFABP, and EFABP in human breast milk are related to nutritional variables of mothers and newborns and thus may play a role in the protective effects of breastfeeding.

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