Surface modification of hydrogels based on poly(2-hydroxyethyl methacrylate) with extracellular matrix proteins
2009
Abstract
Infrared attenuated total reflection spectroscopy was used for in situ observation of the deposition of collagen I on poly(2-hydroxyethyl methacrylate-co-methacrylic acid, 2.9%) hydrogels and subsequent attachment of laminin or fibronectin on the collagen surface. The collagen layers with attached laminin or fibronectin were stable on hydrogel surface in physiological solution.
The modification with collagen and particularly with collagen and laminin or fibronectin allowed the adhesion and growth of mesenchymal stromal cells and astrocytes on the hydrogel surface.