Publication at Second Faculty of Medicine |
2010
Abstract
The concept of personalized medicine is not only an individualized therapeutic management of a patient; its prerequisite is an individualized approach to diagnosis. Most of oncological diagnoses and a many prognostic features are provided by a pathologists.
The pathologist uses not only basic histological methods, but also a morphoproteomic and morphogenomic approaches. Integral part of a contemporary oncological diagnosis is a molecular investigation of a tumour, which can both prove the presence of molecules suitable for targeted therapy, and design a molecular "patient- specific" marker for minimal residual disease monitoring.