Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes
2011
Abstract
The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drug in the retinoblastoma treatment.
This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy.