TEL/AML1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL
2005
Abstract
From the results of this prospective study (the largest published so far), we conclude that TEL/AML1 RQ-RT-PCR can conveniently complement MRD analysis for theprotocol-required risk stratification in childhood ALL if thesecond Ig/TCR target is not available or not adequately sensitive/specific. There is virtually no risk of false-positive result.However, as an under estimation of MRD level by TEL/AML1RQ-RT-PCR remains conceivable in a small percentage of samples (B5%), TEL/AML1 should be used as a second-choice target only and always in a combination with Ig/TCR-based technique.