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Hematological malignancies and solid tumors in pregnancy

Publication |
2009

Abstract

Malignancies during pregnancy are rare, but their incidence is rising due to the fact that women are increasingly postponing pregnancy to a later age. According to IHIS statistics, the average age of first-time mothers and multi-mothers in the Czech Republic has significantly shifted to higher age categories (Fig. 1).

While in 1985 the mean age of the primary pair was 22.3 and the multiparous age was 24.6 years, in 2003 it was 25.9 and 28.1 years.1 The approximate incidence of individual malignancies during pregnancy is shown in Table 1.2. Several studies have shown that terminating a pregnancy in the sense of an abortion does not improve the patient's prognosis.

Exceptions are some rapidly progressing hematological malignancies.2 A specific issue is pregnancy after cancer treatment. Most studies have confirmed a "healthy mother effect" in which women who become pregnant after cancer treatment have a better prognosis than women without a subsequent pregnancy.3-5 with a primarily better prognosis.

Those with more severe diseases do not become pregnant at all.6 Several studies have looked at the most appropriate distance between cancer treatment and pregnancy. Clark et al. monitored patient survival and found a significantly better prognosis in the group of women who became pregnant between 6 and 24 months after completion of treatment compared with women who became pregnant by month 6 (78% vs. 54%). years after the end of treatment.