Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model

Abstract

We identified the presence of a somatic heterozygous R882C mutation in the DNMT3A gene by performing exome sequencing of a pediatric AML case and confirmed this mutation by Sanger sequencing.

Keywords

• acute myeloid-leukemia
• prevalence
• genome
• idh2