Abstract
A study of early vascular rejection lesions in renal allografts in children showed their prevalence in 7.1% in acute rejection (AR). The morphology corresponded to mild or moderate rejection arteritis (v1, v2), or cellular and obliterative arteriopathy (CA, OA).
The changes were found 37 to 336 days after renal transplantation (TPL), respectively. The functional period of grafts with early vascular lesions was considerably shorter than in cases where no vascular lesions developed (p=0.0018).
A study of late vascular rejection lesions in renal allografts showed a prevalence of 24.3% in chronic rejection (CR). Degenerative endarteritis (EAD) was recorded in three cases.
In two out of nine CR grafts examined (22.2%), strong diffuse linear binding of complement C4d fraction, which is at present considered to be a sign of humoral rejection, was proved by immunofluorescence. In these two cases, the course was unfavorable and the grafts failed.
The humoral immune reaction in both acute and chronic rejection.