Inherited polyneuropathy is currently an incurable disease with progressive symptoms affecting young individuals. Complex case management must include education and instruction in appropriate movement and sporting activities.
Moderate strengthening exercises have not been found to be harmful and may reduce the level of muscle paresis while increasing strength and improving the performance of activities of daily living. Customized exercise plans must be regularly reviewed and updated in order to avoid overuse leading to greater muscular weakness, pain and extreme post-exercise fatigue.
The current literature suggests that exercise may be more beneficial if a creatine monohydrate peroral supplement is added to the diet. Current clinical management requires the application of appropriate movement activities for every individual with inherited polyneuropathy, even those whose conditions have progressed to the level of extreme disability.