Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II
Abstrakt
PURPOSE: Cortical dysplasia (FCD) is a frequent cause of epilepsy in childhood. Two major pathological variants are distinguished, FCD type I and II.
The aim of the study was to characterize differences between FCD type I and II. METHODS: Forty children with refractory epilepsy and histopathologically confirmed FCD were retrospectively analyzed.
FCD type I was identified in 24 and FCD type II in 16 patients. CONCLUSIONS: Clinically important differences were found in children with distinct histopathological subtypes of FCD.
Due to prominent neuropsychological deficits and worse seizure outcome, treatment strategies in FCD type I are more challenging than previously reported and these children should be recognized and specifically addressed within the incoherent group of patients with malformative brain disorders.