Abstract
Insulin glargine is a recombinantly produced insulin analogue. The exchange of asparagine for glycine and the addition of two molecular arginines to the molecular structure resulted in the formation of a stable molecule that is soluble in a weakly acidic environment and precipitation in a neutral pH environment under the skin.
The team ensures long-term systemic absorption without significant fluctuations for 24 hours. Patients with type 1 diabetes mellitus had a greater reduction in fasting blood glucose levels compared with NPH insulin.
In patients with type 1 or type 2 diabetes mellitus, a reduction in the percentage of glycated hemoglobin comparable to NPH insulin was observed with a lower incidence of nocturnal hypoglycaemia.