Abstract
Introduction - Type 2 diabetes mellitus is a chronic progressive disease, the constant consequence of which is vascular complications. It has long been clearly shown that higher blood glucose means a higher risk of complications of diabetes.
However, until recently, intervention studies evaluating the effect of improved diabetes compensation on reducing the risk of macrovascular complications have yielded conflicting results. On the one hand, the results of large prospective clinical studies (ADVANCE, ACCORD and VADT, UKPDS) have clearly shown that lowering blood glucose to normal reduces the risk of cardiovascular complications, but on the other hand lead to a revision of the therapeutic strategy for patients with type 2 diabetes.
The results of the ADVANCE study are absolutely crucial for understanding these discrepancies and at the same time for designing an optimal strategy for the treatment of type 2 diabetes.