Fractioned plasmatic separation and adsorption has no influence on the haemodynamic parameters in experimental acute liver failure
Abstract
Objective: Acute liver failure (ALF) is a relatively sparse disease with a very poor prognosis. Its onset is accompanied by haemodynamic instability.
The aim of our study was to evaluate the influence of fractioned plasmatic separation and adsorption (FPSA) on the haemodynamics using an ALF experimental model in large laboratory animals, comparing the results of the experimental and control groups. Design: Experimental study.
Setting: Department of Anaesthesiology and Resuscitation, Central Military Hospital, Prague. Materials and methods: Our experiment included 21 laboratory pigs ( 25-45 kg ) with ALF induced by surgical devascularization.
The onset of ALF was documented by hypoglycaemia ( 0.05) in the experimental group of animals treated with FPSA therapy. A significant decrease of ICP (p < 0.05), a significant decrease of HR at hour 3, a significant increase of CI at hour 9 and a significant decrease of pulmonary artery wedge pressure (PAWP) at hours 6 and 12 were observed.
Conclusion: Our study did not show significant changes of the haemodynamic parameters during the treatment of acute liver failure using the Prometheus device in large laboratory animals.