Jumping translocations in bone marrow cells of pediatric patients with hematologic malignancies: a rare cytogenetic phenomenon
2011
Abstract
Jumping translocations (JTs) are uncommon constitutional or acquired chromosomal aberrations. JTs are caused by the translocation of a section of one chromosome into two or more different recipient chromosomes.
Several mechanisms, such as pericentromeric heterochromatin decondensation, shortened telomeres, illegitimate recombination, virus infection, and chromosome instability, are proposed to induce JTs.