Abstrakt
In this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented. Background: Plasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris.
Methods: During coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry. Results: Five spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications.
Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes. Conclusions: Almost identical proteomic profiles of the stable angina pectoris group compared with the control group corresponded well with clinical results comparing stable patients with the general population.