Abstract
Penicillin V is a natural basic acidostable penicillin for oral use. It inhibits bacterial cell wall synthesis by binding to specific proteins (penicillin binding proteins - PBP) and the bactericidal effect depends on penicillin concentration and activity of the bacterial autolytic system.
Penicillin V is degraded by penicillinase and other bacterial β -lactamases. The drug is readily absorbed after oral administration, bioavailability is about 60 % depending on food intake.
The peak serum concentration is achieved within 0,5-1 h after administration. Penicillin V is the drug of choice for the treatment of streptococcal tonsillopharyngitis, oral cavity infections, stomatological infections and erythema migrans in children.