May titropium therapy influence nitrosative stress in patients with chronic obstructive pulmonary disease (COPD)?
2010
Abstract
The study aimed at determining whether tiotropium therapy influences nitrosative stress in patients with COPD. This is an open study.
Nitrite and nitrate concentrations were measured in exhaled breath concentrate (EBC). EBC was collected before therapy initiation and after 4 and 12 weeks of treatment.
Nitrite concentrations did not significantly change after 4 or 12 weeks of treatment when compared with concentrations prior to the therapy. After 12 weeks of tiotropium therapy, nitrate concentrations were significantly lower than those before the therapy.
Twelve-week administration of tiotropium to COPD patients is able to decrease nitrosative stress (p = 0.010).