M. S-adenosylmethionine does not reduce ischaemia-reperfusion injury to a marginal liver graft in an in-vivo experiment
Abstract
The aim of the study. The aim of our study was to determine whether the use of S-adenosylmethionine reduces ischaemia-reperfusion injury in hepatic grafts with a high degree of steatosis during liver transplantation in rats.
Materials and methods. we used healthy Lewis rats and rats with liver steatosis in our experiment. Rats were divided into four groups of seven animals.
Results. The following ALT values were determined after transplantation at day 14: 1.75 +/- 1.10 μkat/l (ingroup Ia), 1.91 +/- 1.41 μkat/l (in group Ib), 2.13 +/- 1.85 μkat/l (in group IIa) and 2.08 +/- 1.35 μkat/l (in group IIb).
There were no significant differences between these values. GSH values at day 14 post-transplantation were: 44.90 +/- 8.61 μM/mg (in group Ia), 43.82 +/- 8.58 μM/mg (in group Ib), 41.65 +/- 4.87 μM/mg (in group IIa) and 42.71 +/- 4.17 μM/mg (in control group IIb).