Abstract
For over fifty years, metformin has been known as an effective antihyperglycaemic drug not associated with weight gain. In recent years, it has been successfully used in nondiabetic situations as well.
Metformin substitutes for the lack of safe anti-obesity medications, is the drug of choice in women with PCOS and is therapeutically valid in individuals with NASH. The most significant activity of metformin that has been shown recently is its anti-tumorous effect in a number of cancers.