Publication at Second Faculty of Medicine |
2005
Abstract
Insulin analogues are based on the HM molecule of insulin, in which the exchange of some amino acids in the B chain (possibly also in the A chain) results in a structural change in the pharmacokinetic properties. Short-acting insulin analogues, lispro, aspart and glulisine have a faster onset and shorter duration of action than regular, soluble HM insulins and have a significantly lower risk of both early postprandial hyperglycaemia and late postprandial hypoglycaemia.
Administration of the long-acting insulin analogue glargine or detemir will ensure a balanced basal insulin profile with reduced glycemic fluctuation and significantly reduce the frequency of hypoglycaemia (especially at night).