Similar relation of maximal aerobic capacity and risk factors of civilization diseases in long term nephroblastoma survivors and general population
Abstract
Nephroblastoma is the most frequent abdominal cancer in children, mostly unilateral. Median age at diagnosis is 3 years, long term survival rate is 80-90%.
Treatment involves nephrectomy, chemotherapy including cardiotoxic agents some treatment regimens and radiation therapy in advanced stages. Late sequellae include hypertension, decreased renal function, functional disorders of musculoskeletal system and scoliosis.
All of them may affect fitness or are risk factors of civilization diseases. Cohort and methods: 100 patients (57 women), age 8-34 years, at least 5 years in complete remission.
We assessed family history, aerobic capacity, cardiac and renal function. Results: No serious disorders were found using stress EKG and ECHO.
Maximal aerobic capa city is -0,8 SD below population average. Aerobic capacity inversely correlates with blood pressure at rest and during exercise, with BMI and blood triglycerides levels.
There is positive correlation with heart rate reserve. We found pathologic blood lipid profile in 25% and positive family history in 53%.
Conclusion: relation of aerobic fitness and risk factors of civilization diseases is similar to what we found in general population. There are numerous late sequellae of nephroblastoma treatment including hypertension and other risk factors of civilization diseases.
Improving physical fitness can and should be part of secondary prevention.