Publication at Second Faculty of Medicine |
2009
Abstract
Hematopoietic stem cell transplantation from a healthy family or unrelated donor from the registry can be cured for a number of malignant and non-malignant diseases. Healthy cells replace effective, malignant or dysfunctional cells.
When searching for gifts in the registers, the key parameter is the knowledge combination of HLA I. and II characters. class (histocompatibility system of leukocyte antigens), because the mismatch of gifts with the recipient in the alleles of the HLA system is an obstacle to successful transplantation. The hematopoietic stem cell graft itself can be used to overcome the irreversible hematological toxicity of high-dose cancer chemotherapy that does not affect bone marrow cells.