Publication at Second Faculty of Medicine |
2010
Abstract
Familiar and hereditary prostate cancer definition leads modern scientific research to detection of genetic dispositions of a single patient to develop a disease. There were detected a number of candidate genes and genomic areas, where alterations or polymorphisms are frequently present in patients with prostate cancer or in prostate cancer families.
Shb is adaptatiton protein with proapoptotic regulation activity to prostate cancer (PCA) cells. Reduction of tumor growth in vitro has been proved.
Periostin (POSTN) belongs to cell adhesion proteins and plays a significant role in tumorigenesis. Aim of the study was isolation of mRNA from prostate cancer tissue and densitometric measuring of gene expression.