Abstract
Objective: To analyse data on psychomotor and cognitive development of children born after intracytoplasmic sperm injection (ICSI). Design: Open cross-section clinical study.
Setting: Institute for the Care of Mother and Child, Prague and Department of Paediatrics, Charles University, 2nd Medical School and University Hospital Motol, Prague. Methods: In 133 children (75 boys and 58 girls) psychological examination was made at the age range 11 months - 8.5 years in the years 2004-2006.
All children were born after intracytoplasmic sperm injection (ICSI). Psychomotor development of children aged from 11 months to 3.5 years was assessed using the Bayley Scales (BSID-II).
In older children, Global Intelligence McCarthy Test was used. Results: In our sample of ICSI-children, no significantly higher incidence of children delayed in mental (cognitive) as well as in motor development has been found as compared with the population norms.
However, the results indicate a significantly lower average value of the Psychomotor Developmental Index (PDI) in the group of younger children as compared with the given norm (92.3 +- 13.9 versus 100 +- 15; p<0.01). In the group of older children, lower average value of the General Cognitive Index (GCI), as compared with corrected population norm has been found (105.1 +- 14.7 versus 110 +-16; p<0.05).
In the group of twins, a significantly higher number of mild developmental disorders was ascertained on the contrary in the group of singletons (64.7% versus 33.3%; p<0.01) in our older children conceived by ICSI. Conclusion: The results indicate only mild lowering of some performances in our ICSI-children: in motor domain in younger children, and in cognitive domain in older children.
Children from multiple pregnancies are at greater developmental risk than singletons.