Publication at Second Faculty of Medicine |
2011
Abstract
Wegener's granulomatosis is ANCA-associated small vessel vasculitis with extremely malignant prognosis. Cyclophosphamide, together with high-dose corticosteroids, are cornerstone for induction treatment in this diagnosis.
Biologic therapy may offer another option with less adverse effects and could be efficient also in refractory cases. Due to the recent studies, rituximab seems to be most promissing.
Many other biological drugs are also tested in this diagnosis with various success.