Abstrakt
Background: The purpose of our study was to clarify results of surgery for non-small cell lung cancer (NSCLC) and its time trends. Methods: We retrospectively reviewed our prospective database of patients who underwent surgery for NSCLC between 1998 and 2009 in our institution.
Patients were divided into two equal 6-year periods according to the year of surgery (1998-2003 and 2004-2009). Results: One thousand, four hundred and twelve patients underwent operation for NSCLC.
We performed 985 lobectomies with 30-days mortality of 1.8 % and 300 pneumonectomies with 30-days mortality of 5.7 %. Median of survival of all 1412 patients was 4.3 year and 5-year survival was 45 %.
The percentage of female patients, lobectomies and adenocarcinomas increased over time, as well as the age of our patients. Outcome improved over time, with significant decrease in a 30-days mortality after pneumonectomy (8.2 % vs 2.3 %, p=0.029).
The overall 3-year survival improved in patients with stage III (30 % vs 40 %, p=0.012). Conclusion: Outcomes of lung resection for NSCLC improved over time despite a worsening of some elements of preoperative status.
The shift in histological distribution was associated with an increasing proportion of patients with stage I, a lower operative mortality and better 3- and 5-year survival. These trends are due to improvement of preoperative evaluation, preoperative and postoperative care.