Abstract
In recent years, in addition to the treatment of Alzheimer's disease, attention has also focused on its prevention. Some risk factors for Alzheimer's disease are uncontrollable (age, female, ApoE4 genotype), but others can be influenced (including hypertension, diabetes, ischemic heart disease, low education, head injuries).
The most studied of these is arterial hypertension. Several interventional, mostly cardiological, studies have addressed the effect of hypertension on the incidence of dementia.
In the case of nitrendipine, in addition to affecting hypertension, its possible direct effect on the brain is discussed, as its mechanism of action is similar to that of memantium. The primary results of the studies did not provide evidence of the effect of another antihypertensive agent, although these results are probably due to inappropriate study design, as meta-analyzes suggest the importance of hypertension treatment in the prevention of Alzheimer's disease.