Lung Transplantation in Cystic Fibrosis Patients in the Czech Republic: Initial Single-Center Experience
Abstract
Background. Lung transplantation is a well established treatment for advanced lung diseases.
Methods. We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation.
Results. Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list.
The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%.
The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively.
Conclusion. The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature.
We confirmed a less favorable prognosis of BCC-colonized patients.