Effects of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy on Doppler Tei Index: A Midterm Follow-Up
Abstract
Alcohol septal ablation (PTSMA) improves outflow gradient, left ventricular (LV) diastolic function, and symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). Tei index (TI) is a Doppler parameter reflecting both systolic and diastolic LV function.
Midterm changes of TI after PTSMA have not been determined up to now. Twenty-seven consecutive patients (mean age 53 13 years) with symptomatic HOCM underwent PTSMA procedure.
Clinical and echocardiographic data were collected at baseline, 6 and 12 months after PTSMA. TI decreased from 0.67 +/- 0.11 to 0.55 +/- 0.06, isovolumic contractile time (ICT) decreased from 74 +/- 20 to 48 +/- 11 ms, isovolumic relaxation time decreased from 146 +/- 25 to 117 +/- 9 ms, and LV ejection time decreased from 330 +/- 42 to 298 13 ms.
LV remodeling was determined by LV dimension increase from 46 +/- 6 to 48 +/- 6 mm and basal septum thickness reduction from 22 +/- 4 to 15 +/- 3 mm. LV ejection fraction decreased from 78 +/- 7 to 73 +/- 6% and maximal outflow gradient decreased from 69 +/- 44 to 15 +/- 11 mmHg.
All changes were statistically significant (P < 0.01). Symptomatic improvement was characterized by relief of dyspnea (2.5 +/- 0.7 versus 1.4 +/- 0.6 NYHA class; P < 0.01) and angina pectoris (2.6 +/- 0.9 versus 0.7 0.7 CCS class; P < 0.01).
PTSMA is an effective method of therapy for HOCM. Shortening of TI, suggests the improvement of LV myocardial performance in the midterm follow-up.