Abstrakt
Introduction: Little is known about the prognosis of moderate versus critical carotid stenosis treated by carotid artery stenting (CAS). Material and methods: This was a retrospective analysis of a single-centre registry including 271 consecutive patients (69 +/- 9 years, 87% at high risk for surgery), in whom 308 procedures were performed.
The study included both symptomatic (>= 50% carotid artery stenosis) and asymptomatic (>= 70% carotid artery stenosis) patients. The primary endpoint was the rate of adverse events during follow-up (range 1-48 months), defined as all-cause death or stroke.
Results: We treated 115 critical and 193 moderate stenoses and implanted 318 stents (56% with closed cell design). Embolic protection systems were used in 296 cases (96%).
The technical success rate was 98.2% in the critical stenoses group and 99% in the moderate group (NS). During follow-up, the incidence of the primary endpoint was 12.9% (13 pts) in the critical stenoses group and 14.7% (25 pts) in the moderate stenoses group (estimated 3-year freedom from death/stroke was 0.844 vs. 0.812; log-rank test p = 0.983).
Left ventricular ejection fraction < 40%, significant contralateral carotid artery occlusion or stenosis and renal insufficiency were identified as significant predictors of the primary endpoint (p < 0.03). Conclusions: Carotid artery stenting with embolic protection systems in patients at high risk for carotid endarterectomy is safe.
Patients with initially moderate and critical stenoses have an identical mid-term prognosis with regard to death and stroke.