Abstract
Background. The HLA-DPB1 gene is probably one of HLA class II genes affecting the haematopoietic stem cell transplantation.
The aim of the study was to analyse the HLA-DPB1 gene and its match/mismatch in patients transplanted from unrelated HSC donors. The PCR-SSP method was used for the typing of the HLA system.
Methods and Results. The cohort consisted of 201 pairs of patient/unrelated HSC donor.
Match in HLA-A, -B, -Cw, -DRB1 and -DQB1 (e.g. 10/10 match) was found in 81 pairs. The HLA-DPB1 was tested in them. 18 different HLA-DPB1 alleles were identified in this cohort.
Complete match (e.g.12/12) was detected in 3% of the 201 analysed pairs only. Conclusions.
The probability of finding 12/12 matching unrelated HSC donor is limited due to the high percentage of mismatches and inaccessibility of previous HLA-DPB1 results.