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TEL/AML1 and immunoreceptor gene rearrangements - which comes first?

Publikace na 2. lékařská fakulta |
2005

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+immunophenotype.

Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangernents between diagnosis and relapse suggest that in most cases the TEL/AML 1 fusion is formed during immunoreceptor gene rearrangement process.