Abstract
Objective: Cardiac surgery is known to trigger the systemic inflammatory response. While the use of conventional cardiopulmonary bypass (CPB) results in profound inflammation, modified mini-CPB is considered less harmful.
We evaluated effects of cardiac surgery on the expression of CD162, CD166, CD195 molecules and their association with the type of CPB used. Methods and Results: 24 patients were enrolled in our study. 12 of them were operated using conventional CPB while other 12 patients underwent surgery with mini-CPB.
Blood samples were analysed by flow cytometry. We observed the significant increase in CD162, CD195 MFI that peaked instantly after surgery and normalized to the baseline value on the 1st day, whereas CD166 was initially down regulated and its MFI value increased to the baseline in the next few days.
Conclusion: We observed immediate changes in the expression of CD162, CD166, and CD195 molecules on neutrophils after surgery in both study groups of patients. The intensity of observed changes was significantly greater in the group of patients who underwent conventional CPB compared to patients who underwent mini-CPB cardiac surgery.