Abstrakt
Novel imaging diagnostic method - wireless capsule enteroscopy was used in experimental gastroenterology studies in pigs. We monitored the disintegration of two types of drug forms in gastrointestinal tract for next optimalisation of pharmaceutical technology process.
In parallel, the plasma time profiles of the active component were detected. In second study, scanning of intestinal mucous lesions was done as diagnostic tool.
The disintegration of tablets was perceptible in the duodenal-jejunal segment (until the 90th min) and culminated in the proximal jejunum (at the 3rd hour). The peak of maximal concentration was reached between the 3rd and 6th hour.
The most common lesions induced by non-steroidal anti-inflammatory drugs were red spots and erosions. Sensitivity and specificity of capsule endoscopy were more than 80% and 95%, respectively.
Wireless capsule endoscopy is a highly accurate non-invasive method for evaluation of experimental NSAID-induced enteropathy and evaluation of tablet disintegration proces in the intestine.