Does folic acid supplementation rescue defects in ECE-1-deficient mouse embryos?

Abstract

FA supplementation did not result in modified proportions of the genotypes, indicating no rescue of the embryonic mortality. There was also no effect on the litter size.

Craniofacial and cardiac defects were likewise identical in the ECE1 embryos of both groups. These results caution against indiscriminate use of dietary supplements in attempts to prevent congenital anomalies.

Keywords

• endothelin-converting enzyme
• mice
• endothelin 1
• cardiac malformations
• endothelin receptor