Abstrakt
Lamphomatoid papulosis (LyP) is part of the spectrum of primary cutaneous CD30 lymphoproliferative disorders. The disease manifests with self-healing papulonodular skin lesions and exhibits a broad range of histological features.
Five different histological LyP types, refered to as types A to E, have been delineated. The angioinvasive type E is characterized by angiocentric and angiodestructive tumoral infiltrates of medium sized to large CD30 atypical lymphocytes with nuclear pleomorphism.
In the majority of the cases, the tumor cells express CD8, Because of its histological features and the immunophenocytpic findings, this variant of LyP is particularly prone to be misinterpreted as an aggressive lymphoma. This review addresses the clinicopathologic features and differential diagnosis of LyP type E and emphasizes the role of clinicopathologic correlation in the diagnostic workup.