Abstrakt
To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g. 46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity.
We investigated the effect of PPARA intron 7 G/C polymorphism specifically on anaerobic power output in a group of 77 elite male Czech ice hockey players (18-36 y). We determined the relative peak power per body weight (P-max.kg(-1)) and relative peak power per fat free mass (W.kg(-1) (FFM)) during the 30-second Wingate Test (WT30) on bicycle ergometer (Monark 894E Peak bike, MONARK, Sweden).
All WT30s were performed during the hockey season. Overall genotype frequencies were 50.6% GG homozygotes, 40.3% CG heterozygotes, and 9.1% CC homozygotes.
We found statistically significant differences in P-max.kg(-1) and marginally significant differences in P-max.kg(-1) FFM values in WT30 between carriers and non-carriers for C allele (14.6 +/- 0.2 vs. 13.9 +/- 0.3 W.kg(-1) and 15.8 +/- 0.2 vs. 15.2 +/- 0.3 W.kg(-1) (FFM), P = 0.036 and 0.12, respectively). Furthermore, P-max.kg(-1) (FFM) strongly positively correlated with the body weight only in individuals with GG genotypes (R = 0.55; p<0.001).
Our results indicate that PPARA 7C carriers exhibited higher speed strength measures in WT30. We hypothesize that C allele carriers within the cohort of trained individuals may possess a metabolic advantage towards anaerobic metabolism.