Publication at Faculty of Medicine in Pilsen |
2014
Abstract
The current knowledge about a complex process of the immune system ontogenesis in the fetus and neonate is briefly summarized in the article. Development of the neonatal, especially innate immunity, is affected by endogenous, primarily genetic, factors.
Specific (adaptive) immunity is created mainly as a result of external factors including exposure to external pathogens and microorganisms, microbial colonization of the child's gut, nutritional factors, and active immunization.