Abstract
Arundic acid, 2-propyl-octanoic acid is synthetically prepared branched fatty acid which exists in two enantiomers (R) -and (S) -. The biologically active form is (R) -2-propyl-octanoic acid, also known under the code name ONO-2506.
Arundic acid in vitro and in vivo potential neuroprotective compound. It modulates astrocyte activation by inhibiting the enhanced synthesis of protein S-100B protein, responsible for inducing of neuronal death.
It has shown efficacy effective in preventing expansion of cerebral infarction by improving astrocyte function and may be effective, even when administered hours after ischemic stroke onset. Ono-2506 is undergoing phase II development in other neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease.
Ono-2506 does not affect thrombi or blood vessels and therefore does not pose a risk for hemorrhage.