The association between uncarboxylated matrix Gla protein and lipoprotein-associated phospholipase A(2)

Abstract

Lipoprotein-associated phospholipase A2 activity (aLp-PLA2) was associated with desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) The patients in the top quartile of dp-ucMGP had three-fold increase of all-cause mortality, but no effect of high Lp-PLA2 activity was found. We may speculate, that pathophysiology of aLp-PLA2 involves also vascular calcification

Keywords

• Lipoprotein-associated phospholipaseA2
• Matrix Gla protein
• Mortality risk
• Coronary heart disease
• Stroke
• Euroaspire