Publication at Faculty of Medicine in Pilsen |
2014
Abstract
The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the patogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high.
However, the development of adjunctive anti-sepsis therapies has been challenging, with more than 30 unsuccesful drug trials. Fortunately, recent advances in our understanding of the sepsis pathophysiology revealednew pathogenetic paradigms, and, thus, provided new exciting therapeutic concepts.
In this review, we briefly discuss emerging pathogenesis- based strategies for treating severe sepsis and septic shock.