Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine: a multicentre, observer-blind, randomised, controlled trial

Abstract

Background: Rates of varicella have decreased substantially in countries implementing routine varicella vaccination. Immunisation is possible with monovalent varicella vaccine or a combined measles-mumps-rubella-varicella vaccine (MMRV).

We assessed protection against varicella in naive children administered one dose of varicella vaccine or two doses of MMRV. Interpretation: These results support the implementation of two-dose varicella vaccination on a short course, to ensure optimum protection from all forms of varicella disease.

Keywords

• healthy-children
• clinical-practice
• united-states
• mmrv vaccine
• immunogenicity
• safety
• antibody
• persistence
• prevention
• efficacy