Abstrakt
Transdermal absorption of selected PAU (naphtalene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benz[a]anthracene, benzo[a]pyrene) in vitro (Franz cell) through full skin of pig ear was tested. PAHs were applied individually or in mixture containing four PAHs (concentrations of PAHs were the same like by individual application).
Fluxes of all tested PAHs were higher when individually applications were used. The smallest differences between average fluxes (of individual or mixed application) were found in fluorene and naphthalene, the highest differences between average fluxes were found in pyrene and BaA; statistically significant differences were achieved only for pyrene and anthracene (α = 0.05).
Lag time was always greater in the application of a mixture of PAHs. The smallest difference between the average values of the lag time (of individul and mixed application) was found in BaA, the largest in anthracene; a statistically significant difference was only in the case of anthracene (α = 0.01).