Abstract
This study covers the authors' experience with the treatment of bisphosphonate-related osteonecrosis of the jaw based on retrospective analyses of 11 patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol consisted of antimicrobial mouth rinses and systemic antibiotic administration according to the stage of the disease.
Additional surgical debridement and sequestrectomy in combination with antimicrobial therapy was performed in two cases. Complete healing was achieved in six patients.
In two cases, satisfactory healing was noted. Stage of the disease was lowered and only a small area of asymptomatic necrotic bone of up to five mm in diameter persisted.
Two patients developed a stable disease without progression. In one patient, the disease progressed to the third stage with osteonecrosis involving all quadrants of both jaws.
From these data it was concluded that conservative approach in the treatment of bisphosphonate-related osteonecrosis of the jaw led to symptom regression but was not curative. The treatment of bisphosphonate-related osteonecrosis of the jaw is generally difficult.
For this reason, prevention plays a predominant role in the management of the disease.