New perspectives on pharmacotherapy in the algorithm of colorectal cancer liver metastases management
Abstract
Neoadjuvant systemic pharmacotherapy has the potential to convert initially unresectable metastases to resectable ones. The exact criteria for patient selection, optimum therapeutic regime and duration of neoadjuvant therapy, including the timing of surgical intervention, depend on many factors related to the patient (performance status, co-morbidities, etc.) and to the disease (extent and localization of metastases, synchronous vs metachronous form, etc.).
The real conversion rate is likely to be low. Key words: colorectal cancer - liver metastases - treatment - conversion The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE "uniform requirements" for biomedical papers. Submitted: 29. 8. 2014 Accepted: 2. 10. 2014