Acute hemodynamic effects of Riociguat in patients with pulmonary hypertension associated with diastolic heart failure (DILATE-1)

Abstract

Deficient nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension (PH).

Keywords

• PRESERVED EJECTION FRACTION
• SOLUBLE GUANYLATE-CYCLASE
• ENDOTHELIAL DYSFUNCTION
• PHOSPHODIESTERASE-5 INHIBITION
• NITRIC-OXIDE
• GUIDELINES
• COMMUNITY
• DIAGNOSIS
• GENDER
• TARGET