Meaning of cortisol and homocysteine in detection of Alzheimer's dementia - results of the research plan
2014
Abstract
Cortisol and homocysteine are presumed to be risk factors for stress- and age-related disorders, such as Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol or homocysteine concentration with AD.
Plasma cortisol and homocysteine concentration were measured in 80 AD patients, and 37 elderly healthy controls. Plasma cortisol was positively correlated with cognitive impairment in AD patients.
The association of high cortisol and high homocysteine with degree of cognitive impairment or stage of dementia in AD indicate potential role of high plasma cortisol and homocysteine as biomarkers of the disease and/or indicators of brain damage during the progression of AD dementia.